Person A is a champion of compassion, truth, human rights, diversity, tolerance, and love. Become friends with this person at once, and forever shout his/her praises from the mountaintop.
Person B is a hateful, transphobic, ignorant, (and probably religious), bigot. Make every effort to ignore and marginalize them, but if they continue spewing their hate-speech, shout them down. Such intolerance cannot be tolerated.